ALIGNMENT INDEPENDENT 3D-QSAR, QUANTUM CALCULATIONS AND MOLECULAR DOCKING OF MER SPECIFIC TYROSINE KINASE INHIBITORS AS ANTICANCER DRUGS

Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs

Mer receptor tyrosine kinase is a promising novel cancer therapeutic target tillman 750m in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase inhibitors.The frac

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