Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs
Mer receptor tyrosine kinase is a promising novel cancer therapeutic target tillman 750m in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase inhibitors.The frac